Disable "Override Application Settings" per-application - possible?

I would like to know if it is possible to set system antialiasing setting to “Override application settings” globally, and then to let a particular application set antialiasing for itself? (With environmental variables or with recently introduced application profiles.)

Another question is if OpenGL API allows an application to request aliased rendering, so that it would be feasible to enable antialiasing by default without overriding any application settings?

That’s a good idea. I filed request 1306859 to add an application profile option for that.